Preparation of human serum albumin microspheres (MSA) kit for lung imaging in Iran [Persian]
Publish place: Iranian Journal of Nuclear Medicine، Vol: 2، Issue: 1
Publish Year: 1373
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IRJNM-2-1_005
تاریخ نمایه سازی: 7 تیر 1401
Abstract:
Radiolabeled Microspheres of human serum albumin (MSA) is of great importance in the analysis of regional lung perfusion. Preparation of MSA kit has been installed in our Division recently is carried out in two stages: ۱. Production of albumin sphere particles with suitable sizes by using the spinning disk technique. ۲. Formulation of MSA as a radiopharmacutical kit. So it can be labelled simphy with TC - ۹۹m in a short time and uptaken by the lungs within ۱۵ mins when injected intravenously. More than ۹۰% of Microsphere particles of injected dose are trapped by about ۰.۲% of pulmonary capillaries, which remain cssentialy unchanged within the first two hours after injection. After labelling the suspended Microspheres having a diameter between ۱۰-۵۰ mm and there are about ۷۵۰۰۰۰ to ۸۵۰۰۰۰ particles by vial. The biological half life of Microspheres in the lungs is ۴ hours. All the procedure of preparation is under control and each vial is presented sterile, Pyrogen-free Lyophilized Mixture under vacum. No significant antigenic properties have been observed with denatured Albumin. The observed symptoms were attributed rather to the size and quantity of injected Microsphers. Many patients had repeated lung scans. However, no case of anaphylatoid reaction to human albumin microsphere has been reported.
Authors
Ali Asghar Yaraghchi
Department of Radioisotope, Nuclear Research Center, AOEI, Tehran, Iran
Reza Najafi
Department of Radioisotope, Nuclear Research Center, AOEI, Tehran, Iran