Synthesis and Antidiabetic Assessment of New Coumarin-Disubstituted Benzene Conjugates: An In Silico–In Virto Study
Publish place: Journal of Medicinal and Chemical Sciences، Vol: 5، Issue: 6
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JMCH-5-6_003
تاریخ نمایه سازی: 15 تیر 1401
Abstract:
Even with the significant advancements in medical and therapeutical fields, finding efficient anti-diabetic and anti-oxidative entities is of high significance in the recent era. New coumarin-disubstituted benzene conjugates were prepared to evaluate their antidiabetic and antioxidative effects. The prepared conjugates (MT۰-MT۷) were characterized utilizing various analytical techniques, including FTIR, UV–Vis, ۱H-NMR, and ۱۳C-NMR. Also, the drug-likeness properties of conjugates were assessed in-silico. The antidiabetic effect of the prepared conjugates was estimated in-vitro based on their inhibitory impact on porcine α-amylase and yeast α-glucosidase enzymes; whereas their antioxidative effect was appraised in-vitro based on their snaring impact on hydroxide and DPPH radicals. The findings of evaluating these effects demonstrated that the MT۲ and MT۳ conjugates had a prominent antidiabetic effect related to the standard. In addition, the MT۰ conjugate showed a distinct antioxidative effect comparable to that of the standard. Thus, MT۲, MT۳, and MT۰ conjugates could be used as scaffolds to develop a new class of antidiabetic and antioxidative entities. Moreover, the in-silico analysis revealed that the majority of the prepared conjugates had convenient drug-likeness properties for the oral drug-delivery system.
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Authors
Sara Firas Jasim
Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Ninavah-۴۱۰۰۲, Iraq
Yasser Fakri Mustafa
Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Ninavah-۴۱۰۰۲, Iraq
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