Clinical Outcome of Self-administered Vaginal Isonicotinic Acid Hydrazide (INH) Before T۳۸۰A Copper Intrauterine Device Insertion in Adolescent and Young Women: A Double-Blind Randomized Controlled Study

     Background & Objective: To see if ۹۰۰ mg of vaginal isonicotinic acid hydrazide (INH) given ۱۲ hours before insertion of a T۳۸۰A copper intrauterine device (IUD) was more effective than placebo in increasing insertion ease and reducing insertion discomfort in nulliparous ladies. Materials & Methods: A double-blind, randomized controlled study recruited nulliparous women who wanted to use the Copper IUD for contraception. Women who were WHO-eligible for IUD implantation were recruited and randomly assigned (۱:۱) to vaginal INH ۹۰۰ mg or placebo (n=۱۰۰ in each group), ۱۲ hours before the IUD was placed. The primary endpoint was the ease of insertion for the providers. The number of unsuccessful IUD insertions was also recorded. Results: The groups had similar baseline characteristics. The ease of insertion score in the INH group was lower than in the placebo group (۳ (۲-۵).۵ vs. ۶ (۳-۸); P=۰.۰۱), indicating that physicians in the INH group had an easier time inserting the device. The INH group had a reduced mean pain score during the procedure (۳.۹۷ ±  ۰.۹۹۱ vs. ۶.۴۲ ±  ۰.۶۶; P=۰.۰۰۱). In the INH group, two incidences of failed IUD insertion occurred (۲%) compared to four cases in the control group (۴ percent). ۰.۵۹۴ is the p-value. Conclusion: Self-administered INH ۹۰۰ mg vaginally ۱۲ hours before a copper T۳۸۰A IUD insertion successfully reduced discomfort during insertion and improved women's satisfaction and ease of insertion as measured by physicians in nulliparous teenagers and young ladies.  

Keywords:

Intrauterine device , Isonicotinic Acid Hydrazide , Nullipara , Pain