Synthesis, Physicochemical and Biological Studies of Transition Metal Complexes of DHA Schiff Bases of Aromatic Amine

The Transition metal complexes of Cu (II), Ni (II), Fe (III) Co (II) Mn (II) and Cd(II) with DHA Schiff base ligand derived from ۲-aminopyridine were synthesized, characterized by elemental analysis, (FTIR, UV-VIS, ۱HNMR and XRD ) spectroscopic techniques, Thermal and Magnetic study. The antimicrobial (Anti-bacterial and Ant-fungal) activity of ligand and metal complexes have been screened in vitro against ۱) Baccilus Subtilis ۲) Staphyallococcus aureus ۳) Aspergilus niger and ۴) Candida albicans. The composition and structure of synthesized Schiff base ligand and all metal complexes confirmed by elemental analysis, (FTIR, ۱HNMR, UV-VIS and Magnetic study) spectroscopic techniques, Stability of complexes confirmed by thermal study. The synthesized Schiff base ligand and all metal complexes are found to be biologically active. Co (II) and Cu (II) complexes exhibit maximum and Fe (III) complex exhibits minimum zone of inhibition.

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Keywords: Dehydroacetic acid , Schiff bases , Metal complexes , Antimicrobial activity