Association of cardiac enzymes with morbidity and mortality of patients undergoing coronary endarterectomy surgery

BACKGROUND: The relationship between cardiac enzyme release following coronary endarterectomy (CE) and morbidity and mortality is unclear. Therefore, the present study aimed to investigate the association of cardiac enzymes with morbidity and mortality of patients undergoing CE surgery.METHODS: This was a single-center retrospective cohort study of ۴۷۵ patients who had undergone off-pump coronary artery bypass graft (OPCABG). The patients were followed up for a mean of ۷۲.۹۹ ± ۱۴.۶۰ months.RESULTS: Among ۴۷۵ patients undergoing OPCABG, ۳۹ (۸.۲%) were non-survivors. Non-survivors were younger and had a fewer ejection fraction (EF). Comorbidities were similar in survivors and non-survivors. The crude Cox regression analysis showed that creatine kinase-myocardial band (CK-MB) had a protective effect against mortality, but when adjusted with age, sex, diabetes mellitus (DM), hypertension (HTN), hyperlipidemia, smoking, family history, body mass index (BMI), left main disease (LMD), and EF, this effect disappeared. Troponin in crude and adjusted analysis did not have any significant effect.CONCLUSION: There is no association between CK-MB and troponin and mortality in patients undergoing coronary artery bypass graft (CABG).

Keywords:

Biomarkers , Coronary Artery Bypass , Off-Pump , Creatine Kinase , MB Form , Endarterectomy , Troponin