COMPARING THE EFFECTS OF LOVASTATIN AND CORNUS MAS FRUIT ON FIBRINOGEN LEVEL IN HYPERCHOLESTEROLEMIC RABBITS
Publish place: ARYA Atherosclerosis، Vol: 6، Issue: 1
Publish Year: 1389
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_RYA-6-1_001
تاریخ نمایه سازی: 3 شهریور 1401
Abstract:
BACKGROUND: Atherosclerosis, which is a result of gradual deposition of lipids in the lower part of blood vessel endothelium, is the leading cause of mortality and morbidity around the world. It has been proved that some inflammatory blood markers such as fibrinogen can predict the risk for cardiovascular disease conditions, not only in cardiovascular patients, but also in those who do not have any manifestations of the atherosclerotic development. In this study, the effect of cornus mas l. was evaluated on fibrinogen of hypercholesterolemic rabbits and it was also compared with lovastatin drug. METHODS: In this study, ۲۵ New Zealand adult male rabbits were randomly divided into five groups of five. They were treated for ۶۰ days by ۵ different diets, namely basic, high cholesterol, regular plus ۱ g/kgBW cornus mas L. powder, high cholesterol plus ۱ g/kgBW cornus mas L. powder, and high cholesterol plus ۱۰ mg/kgBW lovastatin. At the beginning and at the end of this period, blood samples were collected from the rabbits and their serum fibrinogen levels were measured. RESULTS: Cornus mas L. powder and lovastatin significantly decreased fibrinogen levels in comparison with high cholesterol group (p < ۰.۰۵). Furthermore cornus mas L. powder could reduce the fibrinogen level more than lovastatin (p < ۰.۰۵). CONCLUSION: The results indicated that consumption of cornus mas L. might be beneficial in atherosclerotic patients due to its reducing effects on fibrinogen. Keywords: Atherosclerosis, Fibrinogen, Lovastatin, Rabbits.
Authors
Sedigheh Asgary
Associate Professor of Pharmacognosy, Isfahan Cardiovascular Research Center, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan
Mahmoud Rafieian-Kopaei
Professor of Pharmacology, Shahrekord Medicinal Plants Research Center, Shahrekord University of Medical Sciences, Sharekord
Azadeh Adelnia
MSc, Animal Physiology, Department of Biology, University of Payam-Noor. Isfahan
Somayeh Kazemi
MSc, Animal Physiology, Department of Biology, The University of Isfahan, Isfahan
Fatemeh Shamsi
MSc, Animal Physiology, Department of Biology, University of Payam-Noor. Isfahan