A Comparative Study of NLRP۱ Gene for Iraqi Vitiligo Patients with ۱۰۰۰ Genomes

Generalized Vitiligo (GV) is a complicated disease with many factors that can influence its severity. The GV pathway and its severity are influenced by genetic, epigenetic deleted the comma, and environmental factors. Many genes have been identified at the genetic level that may be involved in this type of disease. As a result, the primary goal of this project is to investigate the impact of some SNPs in the promoter region of the NLRP۱ gene. A total of ۵۰ GV patients and ۲۵۰۴ healthy controls were recruited to see if single nucleotide polymorphisms (SNPs) in the NLRP۱ gene (rs۹۲۵۵۹۵, rs۹۲۵۵۹۶, rs ۹۲۵۵۹۷, rs۹۲۵۵۹۸, rs۱۱۵۶۹۸۹۸, rs۲۷۱۶۹۳۶, rs۷۹۳۷۶۲۷۳, rs۱۱۵۶۹۹۰, rs۸۰۷۲۲۰۳, and rs۲۶۷۰۶۴۲) contribute to determine the relationship between GV and these SNPs, the data was statistically analyzed. Three SNPs (rs۱۱۵۶۹۸۹, rs۹۲۵۵۹۵, and rs۹۲۵۵۹۷) showed a significant association with GV among ten tested SNPs. The three SNPs were found within a linkage disequilibrium block. Haplotypes H۳, H۸, H۹, and H۱۰ which included rs۱۱۵۶۹۸۹, rs۹۲۵۵۹۵, and rs۹۲۵۵۹۷ were found to be associated with GV. The findings suggest that NLRP۱ polymorphisms are linked to GV development.

Keywords:

Generalized Vitiligo (GV) , SNPs , NLRP۱ gene , Autoimmune Disease , rs۱۱۵۶۹۸۹