Immunohistochemical Determination of Estrogen and Progesterone Receptors in Women Breast Cancer Patients

Breast cancer is the first among the top ten cancers as a significant public health issue for women in Iraq. The study was conducted to investigate the association of estrogen and progesterone risks in breast cancer. This study contained sixty paraffin blocks divided into ۴۰ samples of breast cancer blocks and ۲۰ samples of normal breast tissues to examine the expression of estrogen receptors and progesterone receptors in Iraqi patients with breast cancer. The samples were immunohistochemical examined with Dako kits (Dako, Denmark), with higher scores suggesting the presence and density of these receptors (ER and PR). According to the findings of this investigation, the majority of patients were tested positive for ER and PR receptors. There is increasing evidence that ER and PR receptors have a role in the development of breast cancer, making it a desirable protein to become a key target for cancer treatment.

Keywords:

breast cancer , Immunohistochemical study , estrogen receptors , progesterone receptors