Synthesis, Characterization of Nickel (II) Phthalocynine, and Screening of Its Potential Antibacterial Activity

Nickel (II) Phthalocynine (Ni-Pc) is a class of macro-cyclic compounds that has bivalent, tetradentade, planar, and ۱۸ π-conjugated electron aromatic ring systems. Pcs are composed of four pyrrole units linked to four [aza] (—N=C—) groups at the α-carbon of [Pyrrole] unit and they have four aza bridges and four (phenylene) rings. This study aims to synthesize Nickel (II) Phthalocynine. The new synthesized product has been characterized by FT-IR and ۱H-NMR spectroscopy. The procedure of this study includes the synthesis of Nickel (II) Phthalocynine (Ni-Pc) by the reaction of (o-cyanobenzamide) with Nickel that was powdered through heating. Different concentrations of Nickel (II) Phthalocynine were studied regarding the effect of antibacterial activity against two species of bacteria Escherichia coli and staphylococcus aureus by using disk-diffusion methods in Mueller–Hinton agar. The results of synthesis of Nickel (II) Phthalocynine shows a good resistance against the selected bacteria with “the minimum inhibitory concentration” (MIC) and “the minimum bactericidal concentration” (MBC) of (Ni-Pc).

Keywords:

Nickel (II) Phthalocynine , UV-Visible , FTIR and HNMR spectroscopy