Estimation of Asprosin Levels in Female Iraqi Patients with Type ۲ Diabetes and Hypothyroidism

Adipose tissue secretes the hormone asprosin. The asprosin molecule has several roles in the central nervous system and other body systems: hunger, glucose metabolism, insulin resistance (IR), and cellular death. IR is pathologically associated with high asprosin levels. Patients with type ۲ diabetes mellitus (DMІІ) are more likely to have thyroid problems. over time, many diabetics develop thyroid dysfunctional symptoms. the study included ۸۰ women. forty had hypothyroidism with diabetes (DMII), and ۴۰ were healthy controls. gathered samples from the National Diabetes Center, Al-Mustansiriyah University (Iraq), and College of Science for Women/University of Baghdad/Iraq, ۳۵ to ۶۵-year-olds. Dec. ۲۰۲۱-March ۲۰۲۲. the findings of this study indicate that asprosin, FBG, BMI, TSH, cholesterol, triglyceride, VLDL, and LDL concentrations increased significantly when compared to the healthy group. additionally, there was a real decrease in T۳ and HDL levels when compared to the healthy group. Whiles The T۴ level, however, did not show any statistically significant variations. Hypothyroidism and DMIІ patients showed high serum asprosin, which is linked with poor glycemic and lipid management. It's a biomarker for diabetes and thyroid issues.

Keywords:

Asprosin , glucose metabolism , insulin resistance , Hypothyroidism , Thyroid Dysfunction , lipid profile