Effect of Exposure to Quran Recitation on Cell Viability, Cell Migration, and BCL۲L۱۲ Gene Expression of Human Prostate Adenocarcinoma Cell Line in Culture
Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JHSME-5-4_007
تاریخ نمایه سازی: 2 مهر 1401
Abstract:
Background and Objectives: Prostate cancer is the third most important cause of cancer deaths and one of the most common cancers in the world. Given the limited knowledge on environmental sounds and their effects, the important role of sounds is neglected in every culture across the world. The aim of this study was to investigate the impact of Quran recitation on prostate cancer cell line (PC-۳) and compare it with the effects of cisplatin.
Methods: The effects of cisplatin and Quran recitation on the viability and migration capacity of PC-۳ cells were investigated by evaluating BCL۲L۱۲. In addition, mRNAs were assessed by real-time polymerase chain reaction (RT-PCR). Gene expressions of BCL۲L۱۲ and TBP were investigated as target and internal control genes, respectively.
Results: The results of the in vitro assay showed a considerable inhibitory effect of Quran recitation on the proliferation and migration of PC-۳ cells. Furthermore, the significant inhibitory effects of cisplatin on the proliferation and migration of PC-۳ cells exposed to Quran recitation was more than that of the PC-۳ cells only treated with cisplatin. Results of quantitative real time PCR demonstrated that the gene expression of BCL۲L۱۲ was significantly down regulated in PC-۳ cells treated by cisplatin and those exposed to both cisplatin and Quran recitation.
Conclusion: This was the first report about the direct effects of Quran recitation on non-auditory cells in culture. The results of this study suggested that Quran recitation could alter cell proliferation via the down regulation of BCL۲L۱۲ and migration of PC-۳ cells.
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Authors
Ali Mehrafsar
Department of Biology, Zarghan Branch, Islamic Azad University, Zarghan, Iran
Mohammad Javad Mokhtari
Department of Biology, Zarghan Branch, Islamic Azad University, Zarghan, Iran
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