Prevalence and Correlates of the Estrogen and Progesterone Receptors (ER/PR), Human Epidermal Growth Factor Receptor-۲ (HER-۲) and P۵۳ in Breast Cancer: a Cross-Sectional Study
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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JR_JOGCR-7-6_005
تاریخ نمایه سازی: 12 مهر 1401
Abstract:
Background & Objective: Breast cancer has a pivotal role in many deaths caused by malignancies. Epidermal growth factor receptor-۲ (EGFR-۲ or HER-۲) and estrogen receptor (ER) have immense predictive values as prognostic factors. Breast cancers that have steroid receptors and respond to hormone therapy show a better prognosis than cancers without steroid receptors.
Materials & Methods: A retrospective cross-sectional study was performed on ۵۰۰ pathology blocks of women with breast cancer sent to the pathology department of Amir-al-Momenin medical and educational center, Gerash, Iran, from ۲۰۱۶ to ۲۰۱۹. Data were analyzed by SPSS software (Version-۱۶) via ANOVA test followed by Chi-square and t-tests. P-value <۰.۰۵ was considered as significant.
Results: The utmost type of malignancy was invasive ductal carcinoma (IDC) at ۳۵.۰۳%. Among ER-positive patients ۵۹.۶۷% were HER-۲-positive. Nonetheless, among the PR-positive patients ۵۴.۷۴% were HER-۲-positive. ER-positive patients were correlated with p۵۳ receptor, distant metastasis and HER-۲ significantly (P<۰.۰۱). However, PR-positive patients just correlated with p۵۳ receptor significantly (P<۰.۰۱).
Conclusion: Investigated samples were more ER-negative and less PR-positive compared to similar studies. Meanwhile, ER-positive patients were HER-۲-positive. Regarding the correlation with prognosis of breast cancer, especially in HER-۲-positive patients, there is a need to perform profound screening programs for HER-۲ in breast cancer patients, especially with histopathological characteristics of invasive ductal carcinoma.
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Authors
Hakimeh Akbari
Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran
Hossein Forouzandeh
Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran
Tooraj Reza Mirshekari
Department of Pathology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Seyed Adnan Kashfi
Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran
Mehdi Ghavamizadeh
Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran
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