Quinolone antibiotics and their applications in metal complexes: An update

Antibiotics called quinolones have a wide range of action, good oral absorption, and good bioavailability. Quinolones are capable of binding metallic ions and form complexes where they would operate as bidding, unidentating, and bridging ligands because of the chemical features within their nucleus, which include an O۲ atom in the carbonyl group at place ۴, a basic piperazinyl ring at site ۷, and a carboxylic acid job at position ۳. Quinolones hold onto the metal ions to form complexes that could function as bidentates, unidentates, or bridging ligands. Polymeric complexes in a solid state can be coordinated in various ways. Under extremely when exposed to acidic circumstances, quinolone molecules with a base end nucleus protonate and show up as cations in ionic complexes. The pharmacokinetics bioavailability and mode of action of these bactericidal drugs are all impacted by interactions with metal ions, which also have an impact on the solubility, pharmacokinetics, and bioavailability of quinolones. Many metal complexes were revealed to have antibacterial activity equivalent to or greater than the parent quinolones. Novel anticancer medications have come from the novel techniques for the formation of metal complexes of quinolones. The two primary areas of analytical applications of complex formation with metallic ions are metal I detection depending on complexation with quinolones and quinolone determination based on formation of complexes with metal ions.

Keywords:

quinolones , Metal complexes , Bridging Ligands , Unidentates