Suppressive Effects of the Aerial Parts of Datura Stramonium L. Extract on Naloxone-Precipitated Morphine Withdrawal Signs in Mice
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_ZUMS-30-143_012
تاریخ نمایه سازی: 7 آبان 1401
Abstract:
Background and Objective: Datura stramonium L. is a medicinal herb from the family of Solanaceae. It has been used in herbal remedies for promoting health and treating several diseases. The current study was set up to compare the effects of Datura stramonium L. extract on the naloxone-precipitated opiate-withdrawal in mice.
Materials and Methods: Male BALB/c mice (۳۰–۳۵ g, n = ۴۰) were arbitrarily separated into ۴ groups. The control group received morphine and normal saline and other groups received three doses of D. stramonium extract (۱۰, ۲۰, or ۳۰ mg/kg, intraperitoneally, i.p.). Physically dependent was made by the administration of morphine in increasing doses (۵۰-۷۵ mg/kg, i.p.). The withdrawal signs were elicited by intraperitoneal injections of naloxone (۵ mg/kg) ۲ h after the last injection of morphine.
Results: Administration of D. stramonium extract in doses of ۲۰ and ۳۰ mg/kg markedly diminished the jumping numbers compared to the control group (P<۰.۰۵). All three doses of D. stramonium extract could significantly suppress the increase in climbing (P<۰.۰۵, P<۰.۰۰۱, and P<۰.۰۰۱, respectively) and diarrhea (P<۰.۰۰۱). D. stramonium in higher doses (۲۰ or ۳۰ mg/kg) significantly decreased rearing and itching (P<۰.۰۰۱).
Conclusion: The study findings suggest that D. stramonium extract is effective in alleviating the signs of morphine withdrawal. Additional research is needed to determine the exact mechanisms underlying D. stramonium for inhibiting morphine withdrawal syndrome.
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Authors
Sobhan Kasraeifar
Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Amin Mokhtari-Zaer
Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran
Narges Marefati
Dept. of Physiology and Medical Physics, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
Hassan Rakhshandeh
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran
Mahmoud Hosseini
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
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