Premature Neonate With Subclinical Myocarditis Born to a Mother With COVID-۱۹ Infection: A Case Report

Background: In December ۲۰۱۹, COVID-۱۹ caused by the SARS-CoV-۲ appeared in China and then spread to many countries. Like many other medical conditions, infection with SARS CoV-۲ would cause complications during pregnancy and severe illness in pregnant women. Case Report: We reported a premature neonate (۳۱ weeks gestational age, weight ۱۷۰۰ g) with subclinical myocarditis born to a mother with COVID-۱۹. Her mother had no symptoms and confirmed infection with SARS CoV-۲ during pregnancy. Four days after delivery, the mother was diagnosed with COVID-۱۹ infection. The neonate had positive C-Reactive Protein (CRP), elevated cardiac enzymes, and lymphopenia but negative real-time Polymerase Chain Reaction assays (real-time PCR). Her subclinical myocarditis was treated with Intravenous Immunoglobulin (IVIG) and inotrope. We did not use antiviral therapy in medical treatment. The neonate was discharged ۳ weeks after admission with normal cardiac biomarkers enzyme levels and cardiac function in echocardiography. Her follow-up chest x-ray after two weeks was also normal. Conclusion: It seems that subclinical myocarditis can be a complication of COVID-۱۹ in neonates, and this infection could also cause preterm labor in infected pregnant women. Since clinical data on COVID-۱۹ in newborns are still very limited, it is essential to check all the potential complications for pregnant women and their newborns, including cardiac complications.

Keywords:

COVID-۱۹ , SARS-Cov-۲ , Myocarditis , Premature neonate