The effect All-trans retinoic acid on ovarian follicle development inN-MRI mice

Background: Vitamin A (retinol) important for normal growth, vision,reproduction,maintenance of numerous tissues, and overall survival in many species. Objective: In thepresent study the effects of retinoic acid was investigated on Mouse Ovary. Materials andMethods: In this study, newborn female NMRI were injected intraperitoneally with all-transretinoic acid ۲۵ mg/Kg.b.w was dissolved in ۲.۵% DMSO on the day of birth. After ۲۱ dayfemale mice were isolated. They were sacrificd by cervical dislocation at ۶۰ day. The ovariesfrom both groups were fixed and then were used for histological studies. The excised ovariesfrom both groups were weighed. Results:Our results indicate that retinoic acid significantlyincreased the percentage of antral follicles and corpus loteum .Retinoic acid alsosignificantly increased ovary weight (P < ۰.۰۵). Conclusions:According to our findingsretinoic acid can be improve ovulation by positive effect on folliculogenesis.

Keywords:

Ovary , folliculogenesis , Retinoic Acid