Evaluation of the compression properties of co-processed paracetamol, gelatin and microcrystalline cellulose formulation prepared via melt-in agglomeration
Publish place: Trends in Pharmaceutical Sciences، Vol: 8، Issue: 4
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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تاریخ نمایه سازی: 22 آذر 1401
Abstract:
Co-processing techniques have been used to modify the properties of dosage forms. The aim of this study is to evaluate the granules and tablet properties of co-processed paracetamol, gelatin and microcrystalline cellulose. Batches of co-processed paracetamol granules (A-E) were prepared by melt-in agglomeration process using paracetamol with varying amounts of gelatin (۱.۰, ۲.۰, ۳.۰ or ۴.۰ % w/w) or starch (۳.۰ % w/w) and microcrystalline cellulose. A control batch (F) of conventional granules was also prepared by wet granulation method with starch mucilage (۴.۰ % w/w). The granules were subjected to micromeritic, compaction and differential scanning calorimetric analyses. The granules were compressed into tablets and their tablet properties evaluated. Granules of batches A-D had higher percent maximum volume reduction of ۱۲.۲۵-۱۶.۱۳ % compared to the percent maximum volume-reduction (۹.۵۲ and ۱۱.۸۱) of granules from batches E and F respectively. Differential scanning result indicates amorphous solidification of co-processed paracetamol. Tablets formulated from batches A-D showed improve tensile strength (۳.۶۳ - ۸.۲۶ Nm-۲) and faster disintegration time (۱.۳۲- ۱.۱۲ min) compared to the tensile strengths (۵.۰۹ & ۵.۰۱ Nm-۲) and disintegration times (۲.۵۴ & ۴.۴۳ min) of tablets from batches E and F respectively. There were no significant difference (P≥۰.۰۵) in their maximum amounts ( >۷۰ %) of drug released after ۴۰ min. Melt-in agglomeration of paracetamol and gelatin with microcrystalline cellulose created amorphous dispersion that improved tabletability parameters of granules and disintegration time and dissolution properties of tablets.
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Authors
Didacus Nnamani
Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Igbinedion University, Okada, Edo State, Nigeria.
Sylvester Eraga
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City, Edo State, Nigeria.
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