Perspective on Metal-Ligand Coordination Complexes and Improvement of Current Drugs for Neurodegenerative Diseases (NDDs)

Neurodegenerative diseases (NDDs) associated with the steady loss of neural functionality by the action of irreversible damage or death of neurons are one the most serious diseases amongst human beings. The most common NDDs are including Alzheimer’s disease, Prion protein disease, and Parkinson’s disorder. Several coordination complexes are effective in the treatment of NDDs. In the present scenario, computational methods opened a new vista for novel drugs with theoretically improved overall effectiveness. This review highlights the current trends of computational designs of coordination complexes in developing new drug discovery options and their potential to treat different neurodegenerative diseases with up-to-date R&D exploration with future perspectives.

Keywords:

Neurodegenerative Diseases , Metal-ligand complexes , Coordination complexes , Drug , Alzheimer's disease , Parkinson's disease , Prion protein disease