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Antibacterial Activity of Modified Carvacrol against Staphylococcus epidermidis and Pseudomonas aeruginosa

Publish place: Novelty in Clinical Medicine، Vol: 1، Issue: 4
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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لینک ثابت به این Paper:
https://civilica.com/doc/1575991

شناسه ملی سند علمی:

JR_NCLIN-1-4_006

تاریخ نمایه سازی: 11 دی 1401

Abstract:

Background: Carvacrol is the main phenolic compound of Satureja and thyme. Carvacrol has antibacterial, antifungal, anti-inflammatory, and anti-cancer properties.Objectives: The aim of this study is determine the peptide-modified carvacrol’s antibacterial effects against Staphylococcus epidermidis and Pseudomonas aeruginosa.Methods: The peptide-modified carvacrol’s antibacterial activity against Staphylococcus epidermidis and Pseudomonas aeruginosa was investigated by disk diffusion and MIC method.Results: The effects of modified carvacrol by the disk diffusion method had growth inhibition diameters of ۲۵mm and ۲۰mm against Staphylococcus epidermidis and Pseudomonas aeruginosa, respectively. Also, MIC against Staphylococcus epidermidis and Pseudomonas aeruginosa was ۱µg/ml and ۰.۵۱µg/ml, respectively.Conclusion: The peptide-modified carvacrol has some antibacterial effects.

Keywords:

antibacterial , Modified carvacrol , Staphylococcus epidermidis , Pseudomonas aeruginosa

Authors

Mona Ghod Elahi

Department of Organic Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Malak Hekmati

Department of Organic Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Davoud Esmaeili

Department of Microbiology and Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Parisa Ziarati

Department of Medicinal Chemistry, Pharmacy Faculty, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Mohamad Yousefi

Department of Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

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