Aptamer base nanobiosensor for stress hormone measurement
Publish place: Journal of Neurodevelopmental Cognition، Vol: 0، Issue: 4
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JNCOG-0-4_004
تاریخ نمایه سازی: 11 دی 1401
Abstract:
Cortisol plays an important part in the physiological procedures. Observing cortisol concentration as a stress indicator demonstrates physiological mode for diagnosis goal. The mechanism of presented nanobiosensor is LSPR and performed based on the nucleic acid aptamer functionalized with gold nanoparticles which has specific interaction with cortisol. The interaction of aptamer particular measurement of cortisol was accomplished over the concentration from ۰.۰۵ -۰.۲ µg·mL-۱ within ۲۰ minutes. The detection limit is estimated to be ۰.۰۲ µg.mL-۱.
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Authors
Fatemeh Mortazavi Moghadam
Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran; Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham and Women’s Hospital, Cambridge, MA, ۰۲۱۳۹, USA
Mohammadreza Bigdeli
Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran
Su Ryon Shin
Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham and Women’s Hospital, Cambridge, MA, ۰۲۱۳۹, USA