The Role of Neuregulin ۴ Status in Female’s Primary Infertility Patients

Background: Female’s primary infertility (FPI) is females who have not pregnant after one year of sexual intercourse without using methods of birth control. Neuregulin ۴ (NRG۴) is the inflammatory adipokine hormone produced by brown adipose tissues; it has activator function for Epidermal Growth Factor Receptor (EGFR).Objective of the Study: To know the NRG۴ role and function in FPI patients.                         Materials and Methods: The present research study was relied on selecting ۸۰ females classified into ۴۰ with Females having primary infertility and ۴۰ fertile females. All female individuals were in the age range of ۲۰-۳۵ years old. For all female individuals measured NRG۴ concentration level in serum sample and body mass index (BMI). Results: The present research study showed increased of the serum NRG۴ level and BMI in FPI group compared with fertile females group. Statistic value of NRG۴ for FPI group was ۴۲۲.۳+۱۸.۷ and for control group ۲۴۰.۱+۱۷.۸, while the statistic value of BMI for FPI group was ۳۰.۹ + ۱.۷ and for control group ۲۲.۲ + ۲.۵.Conclusion: The present study explained the NRG۴ role that has function as mechanism of compensate in FPI patients with high BMI.

Keywords:

Female’s primary infertility (FPI) , Body mass index (BMI) , Neuregulin ۴ (NRG۴)