The Association between Birth Route and Early/Late onset Neonatal Sepsis in Term Infants: A Case-control Study in the NICU of a Tertiary Hospital in East Java, Indonesia
Publish place: The Iranian Journal of Neonatology، Vol: 13، Issue: 4
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IRJN-13-4_002
تاریخ نمایه سازی: 24 دی 1401
Abstract:
Background: In ۲۰۲۰, neonatal sepsis was recognized as the leading cause of neonatal death. The birth route canaffect the variety of microbial flora in neonates. Microbial colonization through the birth canal is vital to reducesusceptibility to infection. This study aims to identify the association between the birth route and early and late-onsetneonatal sepsis in term infants.Methods: This hospital-based case-control study was carried out on term infants diagnosed with neonatal sepsis at theNICU of a tertiary referral hospital in East Java from ۱ January ۲۰۱۹ to ۳۱ December ۲۰۱۹. Preterm neonates wereexcluded as they may be more likely to develop neonatal sepsis. The Chi-square test and odds ratio (OR) with aconfidence interval of ۹۵% (CI=۹۵%) were used to analyze data. P-value <۰.۰۵ was considered statistically significant. Results: Of ۵۴ patients with neonatal sepsis recruited, the majority had early-onset sepsis (۶۳.۰%) and cesareansection (C-section) delivery (۶۶.۷%). A significant association between birth route and neonatal sepsis onset (p=۰.۰۴۶)was found. However, no significant association was observed between birth route and neonatal sepsis (p=۰.۳۲۱). Terminfants born via C-section were ۳.۲۵ times more at risk (۹۵% CI ۱.۰۰ – ۱۰.۶۰) of early-onset neonatal sepsis thaninfants delivered vaginally. Conclusion: C-section delivery can increase the risk of early-onset neonatal sepsis in term infants.
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Authors
Martono Utomo
Department of Paediatrics, Faculty of Medicine Universitas Airlangga, Dr. Soetomo Hospital, Surabaya, Indonesia
Nabila Harum
Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Kartika Nurrosyida
Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Mahendra Arif Sampurna
Department of Paediatrics, Faculty of Medicine Universitas Airlangga, Dr. Soetomo Hospital, Surabaya, Indonesia
Talitha Yuliaputri Aden
Department of Paediatrics, Faculty of Medicine Universitas Airlangga, Dr. Soetomo Hospital, Surabaya, Indonesia
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