Protective effect of hot peppers against amyloid Aβ peptide and brain injury in AlCl۳ induced Alzheimer’s disease in rats
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 26، Issue: 3
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-26-3_010
تاریخ نمایه سازی: 8 بهمن 1401
Abstract:
Objective(s): This study investigated the therapeutic effect of red hot pepper (Capsicum annuum) methanolic extract in induced Alzheimer’s disease using AlCl۳ in male rats. Materials and Methods: Rats were injected with AlCl۳ intraperitoneally (IP) daily for two months. Starting from the ۲nd month of AlCl۳, rats received, in addition, IP treatments with Capsicum extract (۲۵, ۵۰ mg/kg) or saline. Other groups received only saline or Capsicum extract at ۵۰ mg/kg for two months. Brain levels of reduced glutathione (GSH), nitric oxide (NO), and malondialdehyde (MDA) were determined. Additionally, paraoxonase-۱ (PON-۱) activity, interleukin-۶ (IL-۶), Aβ-peptide, and acetylcholinesterase (AChE) concentrations in the brain were measured. Behavioral testing included wire-hanging tests for neuromuscular strength and memory tests such as Y-maze and Morris water maze. Histopathology of the brain was also done. Results: Compared with saline-treated rats, AlCl۳ caused significant elevation of brain oxidative stress as GSH level and PON-۱ activity were depleted along with MDA and NO level elevation in the brain. There were also significant increases in brain Aβ-peptide, IL-۶, and AChE levels. Behavioral testing indicated that AlCl۳ decreased neuromuscular strength and impaired memory performance. Capsicum extract given to AlCl۳-treated rats significantly alleviated oxidative stress and decreased Aβ-peptide and IL-۶ in the brain. It also improved grip strength and memory functioning and prevented neuronal degeneration in the cerebral cortex, hippocampus, and substantia nigra of AlCl۳-treated rats. Conclusion: Short-term administration of ASA (۵۰ mg/kg) has adverse effects on male reproductive function in mice. Co-administration of melatonin protects against ASA-induced impairment of male reproductive function by preventing the reduction in serum TAC and testosterone levels seen with ASA treatment alone.
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Authors
Omar Abdel-Salam
Department of Toxicology and Narcotics, Medical Research, and Clinical Studies Institute, National Research Centre, Cairo, Egypt
Marwa El-Shamarka
Department of Toxicology and Narcotics, Medical Research, and Clinical Studies Institute, National Research Centre, Cairo, Egypt
Eman Youness
Department of Medical Biochemistry, Medical Research, and Clinical Studies Institute, National Research Centre, Cairo, Egypt
Nermeen Shaffie
Department of Pathology, Medical Research, and Clinical Studies Institute, National Research Centre, Cairo, Egypt
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