Solid Phase Extraction of Letrozole by a Metal Organic Framework and its HPLC-UV Characterization
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_ANALCH-8-2_008
تاریخ نمایه سازی: 16 بهمن 1401
Abstract:
We successfully synthesized TMU-۲۴ as metal-organic framework (MOF) and employed as an effective sorbent for preconcentration of the letrozole (LTZ) from biological samples. Using high-performance liquid chromatography with UV detector (HPLC-UV) coupling with solid-phase extraction (SPE) a sensitive, fast, and simple method for deteing of LTZ has been developed. The optimal conditions, such as pH, type of eluent solvents, contact time amount of adsorbent, and adsorption capacity were discussed. Under the optimized conditions, relative recoveries (RR) and preconcentration factor (PF) of the LTZ was obtained in the range of ۹۲.۴–۹۹.۶% and ۳۳ respectively. Under the optimal conditions, LTZ can be determined with a limits of detection (LODs) ۰.۵ μg L-۱ (based on S/N = ۳), a linearity in the range of ۱–۲۵۰ μg L-۱, and a reasonable linearity of ۰.۹۹۵. Also, the experimental adsorption isotherms models were investigated. The developed method was successfully used to the analysis of LTZ in urine samples.
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Authors
Soheila Mohammadi
Nano Drug Delivery Research Center, Health Technollogy Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
mahnaz hazrati
Nano Drug Delivery Research Center, Health Technollogy Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
yadollah yamini
Department of Chemistry, Tarbiat Modares University, P. O. Box: ۱۴۱۱۵-۱۷۵, Tehran, Iran
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