Anti-inflammatory influences of royal jelly and melittin and their effectiveness on wound healing

Royal jelly is a valuable medicinal substance that has different biological functions in various tissues and cells and has many medicinal features including anti-allergic, anti-tumor, antioxidant, and anti-inflammatory activities and also has protective effects on the immune, reproductive, nervous, and vascular systems. Melittin, which is a peptide with ۲۶ residues, is the key element of honey bee venom and has cytotoxic, antibacterial, anticancer, and anti-inflammatory effects. Royal jelly can ameliorate the inflammatory response in microglia through the inhibition of p۳۸ phosphorylation, and by inhibiting the NF-KB nuclear translocation. By decreasing the secretion of pro-inflammatory molecules including TNF-α, IL-۱ß, and NO, melittin could apply the anti-inflammatory impacts on several kinds of cells including microglial cells. Royal jelly components may enhance the healing of wound via an anti-inflammatory effect, promotion of the growth factors synthesis, or the fibroblasts or skin keratinocytes migration. Based on multiple biological and pharmacological activities, a kind of formulated melittin is possibly capable to promote the healing of wound. The aim of this review is to narrate the anti-inflammatory effects of royal jelly and melittin and their efficiency on wound healing.

Keywords:

Royal Jelly , melittin , Inflammation , wound healing