Expression of MicroRNA-۱۵۵-۵p in Chronic Kidney Disease as a Potential Marker of Cardiovascular Complications

Background: Chronic kidney disease (CKD) is a silent, serious condition requiring reliable non-invasive markers for diagnosing and predicting complications especially cardiovascular (CV)complications.Objectives: This study aims to detect microRNA-۱۵۵-۵p (miR-۱۵۵-۵p) as a potential marker of CKD and a predictor of CV complications.Subjects and methods: ۱۲۰ participants were included in this study, and they were categorized as; Group I (n=۶۰, healthy age- and sex-matched control group) and Group II (n = ۶۰, CKD patients). Group II was subdivided into: Group IIA (n = ۳۰ CKD patients without CV complications) and Group IIB (n = ۳۰; CKD patients complicated with CV diseases). Using reverse transcription polymerase chain reaction (RT-PCR), miR-۱۵۵-۵p was detected.Results: miR-۱۵۵-۵p was increased in Group IIA and IIB compared with the control group, while miR-۱۵۵-۵p was increased in Group IIB compared with Group IIA.Conclusion: miR-۱۵۵-۵p can be used as a sensitive and specific marker for detecting CKD and discriminating between CKD with and without CV complications.

Keywords:

Chronic kidney disease MicroRNA , ۱۵۵ , ۵p Cardiovascular complications Glomerular filtration rate Polymerase chain reaction