Metal exposure and breast malignancy: A case-control study of Malwa Region of Punjab
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نوع سند: مقاله ژورنالی
زبان: English
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JR_EHEM-10-1_010
تاریخ نمایه سازی: 19 فروردین 1402
Abstract:
Background: Breast cancer is triggered by uncontrollable breast cell development. These metals may build up in human serum and tissues, causing estrogenic/malignant consequences. Therefore, metals are being studied to investigate whether they enhance the risk of endocrine-related malignancies like breast cancer.
Methods: This study assessed the level of metals such as Cd, As, Pb, Ni, Cr, Zn, and Fe in ۱۲۰ women undergoing breast cancer surgery in the Malwa region of Punjab. Subjects having malignant breast lesions (n = ۸۳) were grouped in the cancer case group whereas subjects with benign breast lesions (n = ۳۷) were separated as a control group. From each case, blood, breast tumor, surrounding adipose tissue samples were obtained, and metal analysis was carried out using inductively coupled plasma mass spectrometry (ICP-MS).
Results: In malignant cases, the amount of metals ranges from ۰.۰۴ to ۱۳۹.۱۸ μg/kg in tumor. Whereas in adipose tissues and blood, it ranges from ۰.۰۴ to ۱۱۶۴.۰ μg/kg and from ۰.۰۲ to ۲۷۶.۶۱ μg/kg, respectively. In control group, the total amount ranges from ۰.۰۵ to ۳۳۲.۷۲ μg/kg in the tumor, from ۰.۱۳ to ۱۲۵.۶۱ μg/kg in adipose tissues, and from ۰.۰۱ to ۱۲۱.۷۶ μg/kg in the blood. The level of Cd, Cr, Zn, Fe, Ni, and Pb were observed to be statistically significant/extremely significant whereas Arsenic was detected in no groups.
Conclusion: The results indicate that Cd, Cr, Zn, Fe, Ni, and Pb may play a significant role in the development of breast cancer. The parenchymal component of tumor tissues accumulates heavy metals at a higher rate.
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Authors
Akriti Sharma
Corresponding author: Department of Chemistry, University Institute of Sciences, Chandigarh University, Mohali, Punjab, India
Nidhi Rani Gupta
Department of Chemistry, Multani Mal Modi College, Patiala, Punjab, India
Nishtha Hooda
Department of Computer Science and Engineering, Indian Institute of Information Technology, Una, Himachal Pradesh, India
Renu Sharma
Department of Chemistry, University Institute of Sciences, Chandigarh University, Mohali, Punjab, India
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