Effect of fetuin-A on adenine-induced chronic kidney disease model in male rats
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 26، Issue: 5
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-26-5_003
تاریخ نمایه سازی: 28 فروردین 1402
Abstract:
Objective(s): This study aimed to investigate the possible effects of fetuin-A on an adenine-induced chronic kidney disease (CKD) model in male rats. Materials and Methods: Rats were divided into three groups: group A included rats fed a normal diet; group B included rats fed a normal diet with ۲۲۰ mg/kg adenine daily for ۲۱ days; group C included rats fed a normal diet with ۲۲۰ mg/kg adenine daily for ۲۱ days and intraperitoneally administered with ۵ mg\kg fetuin-A every other day for ۲ weeks. Serum samples were assayed for serum creatinine, urea, sodium, potassium, calcium, phosphorus, tumor necrosis factor (TNF), interleukin-۶ (IL-۶), and estimated glomerular filtration rate (eGFR), and immunohistochemical staining was performed.Results: Group B showed a significant increase in serum creatinine, urea, phosphorus, potassium, TNF, and IL-۶ and a significant decrease in serum sodium, calcium, and eGFR compared with group A. Regarding immunohistochemistry, group B showed increased apoptosis. In group C, fetuin-A reduced the urea, creatinine, and phosphorus levels, and in group C, fetuin-A decreased inflammation and apoptosis by reduction of caspase-۳ staining.Conclusion: Fetuin-A improved kidney function in CKD due to its anti-inflammatory and anti-fibrotic role.
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Authors
Wesam Ashour
Physiology Department, Faculty of Medicine, Zagazig university, Sharqia government, Egypt
Mohamed Sayed Ahmed Zamzam
Physiology Department, Faculty of Medicine, Zagazig university, Sharqia government, Egypt
Heba Essam El Din El Sayed Ali
Physiology Department, Faculty of Medicine, Zagazig university, Sharqia government, Egypt
Reham Hassan Ebrahim
Physiology Department, Faculty of Medicine, Zagazig university, Sharqia government, Egypt
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