The Effect of Microchannel Geometry to MaximizeSeparation Efficiency of Blood Particles (Exosomes)in The Presence of Acoustic Field

In this study, we propose a new microchannel geometry to isolate exosomes from whole blooddirectly using acoustofluidics. A convex and concave microchannel was used in this paper.Also, Software COMSOL® was used to simulate the movement and separation effects of theparticles under different stages of the acoustic radiation force. This study aimed to model acomplete form of acoustophoretic blood cell separation considering standing surface acousticwaves (SSAWs) simulation-ally through optimizing the microchannel geometry whileseparating exosomes. The results of the study showed that the design of the microfluidicchannel, the channel length, and the flow rate can be applied to the separation of particles withdifferent microfluidic sizes, in a shorter period of time and with minimal damage to the sample.In the exosome-isolation simulation, we achieved a faster way that causes the exosomes toconcentrate better, so they were better separated from the bloodstream with a purity of ۹۷.۳ %.

Keywords:

Microfluids , Standing surface acoustic wave (SSAW) , Exosomes , Microchannel