Hepatic regenerative response to long-term consumption of cinnamon-rich diet in aged rats

Objective: The present study aimed to investigate the impact of cinnamon on liver regeneration in a rat model of partial hepatectomy (PH).Materials and Methods: Thirty-two old male Sprague-Dawley rats (۱۲ weeks old) were randomly divided into two equal groups (n=۱۶). One group was fed with a standard diet (control) while the other group was fed with the same diet containing ۱% cinnamon for ۴۱ weeks. Then, all animals were subjected to the PH procedure and their livers were studied on postoperative days ۲, ۱۰ and ۲۸. The liver contents of hepatic growth factor (HGF), insulin, malondialdehyde (MDA), nitric oxide metabolites (NOx), superoxide dismutase (SOD) and tumor necrosis factor-alpha (TNF-α) were evaluated. Also, the serum levels of liver function markers (alanine aminotransferase (ALT) and aspartate aminotransferase (AST), MDA, NOx and SOD activity were measured.Results: The regenerated liver weight was significantly higher in cinnamon-treated animals than the controls on both day ۱۰ and ۲۸ post hepatectomy. The hepatic MDA levels in the cinnamon-treated animals were significantly lower than the control rats. Cinnamon led to a significant increase of SOD on day ۲ after hepatectomy in serum and liver content. The basal level of HGF in the liver of cinnamon-consuming rats was significantly higher than in the control rats. Hepatic insulin level was significantly increased relative to baseline and control on day ۲ in the cinnamon-consuming rats. Hepatic TNF-α levels dramatically decreased on postoperative days (POD) ۲ relative to baseline in the control and cinnamon-treated rats.Conclusion: Long-term cinnamon consumption enhanced liver regeneration outcomes in old rats.

Keywords:

Cinnamomum zeylanicum , Liver resection , Oxidative stress , ageing , HGF , TNF-α , Nitric oxide , Regeneration