Age and Cervical Histology, the Most Important Factors to Predict Human Papilloma Virus Clearance

Background & Objective: Cervical Cancer (CC) is a common cancer which is associated with HPV-infection. The aim of this study is to investigate the risk factors which affects HPV-clearance.Materials & Methods: This study was carried out on women with high risk HPV infection. All the patients underwent pap smears and cervical biopsy. Demographic data, marital status, vaccination history and consumption of tobacco, alcohol, opium and oral contraceptive pills were asked through a questionnaire. Results: The results showed that in one year follow-up, ۱۴۲ (۶۷.۱%) patients showed HPV clearance. The HPV clearance decreased by increasing age (P=۰.۰۲۸) or higher CIN grades (P=۰.۰۱۷). In case of parity, there was no significant difference in univariate analysis (P=۰.۱۴۷), but it was significant in multiple logistic regression analysis (۹۵% CI: ۰.۴۱۳-۰.۹۴۱, OR=۰۶۲۴, P= ۰.۰۲۴).Conclusion: It seems that age and cervical histology at the start of HPV infection are the most important factors for HPV clearance.

Keywords:

HPV , persistence , Clearance , cervical cancer