Predictors of Mortality in Sepsis Patients Resulting from Severe and Critical COVID-۱۹

Patients with severe and critical COVID-۱۹ may exhibit sepsis and mortality resulting from multi-organ failure. Neutrophil-lymphocyte-ratio (NLR) values, C-reactive protein (CRP) levels, sequential organ failure assessment (SOFA), and acute physiology and chronic health evaluation II (APACHE-II) scores were used to assess the risk of mortality in sepsis patients resulting from severe COVID-۱۹ infection. The adequacy of NLR, CRP, SOFA, and APACHE-II scores were evaluated as predictors of mortality in septic COVID-۱۹ patients at Dr. Kariadi Hospital Semarang, Indonesia, between August ۲۰۲۱ and July ۲۰۲۲. The subjects included severe and critical COVID-۱۹ patients who fulfilled the WHO interim guidelines and Sepsis-۳ criteria. A total of ۲۱۱ patients were included, which were divided into survivor (n = ۱۱۶) and non-survivor (n = ۹۵) groups. NLR values, CRP levels, SOFA, and APACHE-II scores were measured within ۲۴ hours of patient admission. Univariate and multivariate logistic regression analyses were used to identify the risk factors for COVID-۱۹ mortality. Receiver operating characteristic curve analysis was used to predict the mortality of severe COVID-۱۹ patients. The results indicated that the APACHE-II score was an independent predictor of mortality in sepsis patients resulting from severe and critical COVID-۱۹.

Keywords:

Neutrophil , Lymphocyte , ratio (NLR) C , reactive protein (CRP) SOFA score APACHE , II score Mortality COVID , ۱۹