Evaluation of GATA۳ and GCDFP۱۵ Expression in Triple Negative Breast Cancers
Publish place: IRANIAN JOURNAL of PATHOLOGY، Vol: 18، Issue: 1
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJP-18-1_010
تاریخ نمایه سازی: 26 اردیبهشت 1402
Abstract:
Background & Objective: Breast cancer is one of the most common cancers in the world. There are some different types of breast cancer and triple-negative breast cancer is the type in which no receptors for estrogen, progesterone, and human epidermal growth factor receptor-۲ are expressed. Identifying factors that can facilitate the diagnosis of triple-negative breast cancer is important. In this study, we decided to investigate the expression of GATA۳ and GCDFP۱۵ genes in triple-negative breast cancers.Methods: This is a retrospective descriptive-analytical study that was performed on ۵۰ specimens of samples of triple-negative breast cancer. Data including age and sex, tumor grade, tumor size, types of invasion, GATA-۳, and GCDFP-۱۵ were assessed.Results: The mean age of the patients was ۴۸.۳±۱۴.۱۷ years. Of the total specimens, ۴۶% were positive for GCDFP۱۵ and ۹۰% were positive for GATA-۳. The intensity of GATA۳ was evaluated and it was observed that ۳۳(۷۳.۳%) of the cells were strongly stained and ۱۲(۲۶.۷%) were weakly stained. There were no relationships between GATA-۳ and GCDFP-۱۵ with tumor characteristics.Conclusion: GATA-۳ and GCDFP-۱۵ may serve as diagnostic markers for triple-negative breast cancers and GATA-۳ seems to be more reliable.
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Authors
Mahsa Ahadi
Men’s Health and Reproductive Health Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Afshin Moradi
Men’s Health and Reproductive Health Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Elham Rabiee
Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Fatemeh Pourmotahari
Clinical Research and Development Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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