Copper Based N,N-Dimethyl-N-(۱-Pyridinylmethylidene) Propane-۱,۳-Diamine Compound: Synthesis, Characterization, and Its Application toward Biocidal Activity
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JAOC-3-2_001
تاریخ نمایه سازی: 21 خرداد 1402
Abstract:
The N۳ tridentate ligand N,N-dimethyl-N-(۱-pyridinylmethylidene) propane-۱,۳- diamine (DPMPD) and its copper complex (CDPMPD) were synthesized of which metal complex is found in green colour powdered form. The associated spectroscopic techniques were used to characterize both ligand and the metal complex. Powder XRD method was utilized using the Scherrer formula to accomplish the grain size of the metal complex. It was found that the experimental results of the powdered complex were quite similar to that of the reference material with JCPDS ID ۰۰- ۰۲۴-۱۹۷۷. In vitro anticancer activity shows that the metal complex exhibits a moderate cytotoxic effect on Hep-G۲ cell line. This cytotoxic phenomenon is well supported by a molecular docking study using target topoisomerase II crystal structure (PDB id ۴FM۹). The HOMO- LUMO energy gap, predicted from the DFT study, signifies that the complex is susceptible to chemically reactive.
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Authors
Rajesh Das
Department of Chemistry, University of North Bengal, Bengal, India
Deboshmita Mukherjee
Department of Chemistry, University of North Bengal, Bengal, India
Sahin Reja
Department of Chemistry, University of North Bengal, Bengal, India
Kaushik Sarkar
Department of Chemistry, University of North Bengal, Bengal, India
Ambica Kejriwal
Department of Chemistry, University of North Bengal, Bengal, India
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