Aptamer base nanobiosensor for stress hormone measurement
Publish place: Journal of Neurodevelopmental Cognition، Vol: 3، Issue: 1
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JNCOG-3-1_004
تاریخ نمایه سازی: 29 خرداد 1402
Abstract:
Cortisol plays an important part in physiological procedures. Observing cortisol concentration as a stress indicator demonstrates the physiological mode for the diagnosis goal. The mechanism of the presented nano biosensor is LSPR and is performed based on the nucleic acid aptamer functionalized with gold nanoparticles which have specific interaction with cortisol. The interaction of aptamer particular measurement of cortisol was accomplished over the concentration from ۰.۰۵ -۰.۲ μg·mL-۱ within ۲۰ minutes. The detection limit is estimated to be ۰.۰۲ μg.mL-۱.
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Authors
Fatemeh Mortazavi Moghadam
Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran; Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham and Women’s Hospital, Cambridge, MA, ۰۲۱۳۹, USA
Mohammadreza Bigdeli
Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran
Su Ryon Shin
Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham and Women’s Hospital, Cambridge, MA, ۰۲۱۳۹, USA