Cerebellar Plasticity Changes in an Experimental Model of Autism Induced by Maternal Separation
Publish place: Journal of Neurodevelopmental Cognition، Vol: 3، Issue: 1
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JNCOG-3-1_002
تاریخ نمایه سازی: 29 خرداد 1402
Abstract:
Autism is a neurodevelopmental disorder with a complex pathophysiology that affects different areas of the brain. Evidence over the past decade indicated a role for the cerebellum in social skills in connection with neuropathological changes. In this study, we examined cerebellar plasticity in rats that exhibited autistic-like behaviors after maternal separation (MS). We showed that autistic-like behaviors were associated with changes in cerebellar volume size. We for the first time showed the decreased volume of the cerebellum in the maternal separation animal model of autism, supporting the involvement of the cerebellum in the pathophysiology of autism.
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Authors
Monireh Mansouri
Institute for Cognitive and Brain Sciences, Shahid Beheshti University, Tehran, Iran
Faeze Mashayekhi
Institute for Cognitive and Brain Sciences, Shahid Beheshti University, Tehran, Iran
Maryam Ardalan
Centre for Perinatal Medicine and Health, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden