Molecular Epidemiology of Hepatitis C Virus Infection― Status Quo and outlook

AbstractHepatitis C virus (HCV) infection has been a global health problem and, according to the recent report, more than ۷۱ million people (which equals to almost ۱% of population) have HCV infection. Onset of HCV infection is often acute and asymptomatic. In majority of cases, especially in underdeveloped countries, HCV infection remains undiagnosed for a long time. HCV has eight different genotypes, named from one to eight, which differ from each other at ۳۱%-۳۳% of nucleotides. Each genotype is further classified into several subtypes. Collectively, ۸۶ subtypes have been recognized which differ from each other at < ۱۵% nucleotide sequence. Determination of genotype of pathogen has been proven an effective means from the aspect of epidemiology. It is an important stage in the processes of decision-making and selecting appropriate therapeutic regimen. Studies have indicated that certain genotypes are found in countries or regions where direct acting antivirals are available against HCV infections. Developing awareness

Keywords:

Molecular epidemiology , Hepatitis C virus , Genotype determination , Nucleotides , Awareness programs