Comparative Study Between Superficial and Deep Myometrial Invasion in Endometrial Cancer Type ۱ in Relation to Regional Lymph Nodes Metastasis

Background & Objective: The present study compares between superficial and deep myometrial invasion in type ۱ endometrial cancer in relation to regional lymph nodes metastasis, so we can answer the question to do or not do lymphadenectomy, this life-threatening procedure in both superficial and deep myometrial invasion with type ۱, clinically and radiologically stage ۱ endometrial cancer.Materials & Methods: Patients were divided into ۲ groups distributed as follows: group I includes ۵۰ patients type ۱ endometrial cancer with superficial myometrial invasion and group II includes ۵۰ patients type ۱ endometrial cancer with deep myometrial invasion. Total abdominal hysterectomy with bilateral salpingo-opherectomy with pelvic and lower para-aortic lymphadenectomy to all patients included in the study from both groups. Histopathological examinations were done to all the specimen from both groups to confirm diagnosis of type ۱ endometrial cancer, depth of myometrial invasion, pathological grading and metastasis to the regional lymph nodes.Results: Considering regional lymph nodes metastasis in both groups, there is a statistical difference between group I and group II in relation to regional lymph nodes metastasis as group II (cases with deep myometrial invasion) are associated with more regional lymph nodes metastasis (P= ۰.۰۰۰۱)).Conclusion: Deep myometrial invasion in type ۱ endometrial cancer is associated with significant increase in regional lymph nodes metastases.

Keywords:

Endometroid adenocarcinoma , deep myometrial invasion , regional lymph nodes metastases , Lymphadenectomy