Regenerative Medicine and Perioperative Hypoxic Organ Damage: Targeting Hypoxia-Inducible Factors

Regenerative medicine is defined by utilizing the body’s repair mechanisms to restore the normal function of tissues. An important perioperative issue for anesthesiologists is organ damage that is caused by hypo-perfusion mostly due to hypoxia. Our body’s response to low oxygen concentration promotes a genomic pathway to increase the level of hypoxia-inducible factors (HIFs). Regenerative medicine can help to heal damaged tissue in the perioperative period. This review introduces HIFs and their protective effect in various organs, especially during surgery, as a pioneering role of regenerative medicine to prevent perioperative complications.

Keywords:

Anesthesia , Hypoxia-Inducible Factor ۱ , Perioperative medicine , Regenerative medicine