Comparative study of histopathological diagnostic criteria in cutaneous lesions of lichen planus and discoid lupus erythematosus
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نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_SKUMS-24-2_006
تاریخ نمایه سازی: 28 تیر 1402
Abstract:
Background and aims: Lichen planus (LP) and discoid lupus erythematosus (DLE) are two relatively common mucocutaneous lesions
whose clinical and histopathological features overlap in some cases. The present study aimed to distinguish between these two lesions
histopathologically in order to treat them more accurately.
Methods: In a cross-sectional descriptive-analytical study, ۲۹ and ۴۸ microscopic slides of skin samples of DLE and LP, respectively,
were examined in the pathology archive of Al-Zahra hospital of Isfahan from ۲۰۰۸ to ۲۰۱۸. The slides prepared by hematoxylin-eosin
staining were examined simultaneously and blindly by three pathologists with a light microscope and compared according to certain
histopathological criteria. Then obtained data were analyzed by SPSS version ۲۴ using chi-square, Fisher’s exact, Mann-Whitney, and t
tests (P < ۰.۰۵).
Results: Based on the findings, the presence of hyperparakeratosis with superficial hyperorthokeratosis, epithelial atrophy, deep perivascular
infiltration, presence of edema in the papillary dermis, presence of plasma cells with lymphohistiocytes in inflammatory infiltration, and
presence of mucin in the dermis were significantly higher in DLE than in LP (P < ۰.۰۵). On the other hand, the intensity of lichenoid
infiltration, presence of saw tooth hyperplasia of rete ridges, presence of cleft between the epithelium and connective tissue, spongiosis,
hyperorthokeratosis alone, and wedge-shaped hypergranulosis were significantly higher in LP than in DLE (P < ۰.۰۵).
Conclusion: Perieccrine and perifollicular inflammation, presence of Civatte bodies (CBs), abundance of fibrosis, presence of pale
keratinocytes, and presence of pseudoepitheliomatous hyperplasia were not the criteria for differential diagnosis of LP and DLE.
Keywords:
Authors
Parviz Deyhimi
Department of Oral and Maxillofacial Pathology, Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
Forouz Keshani
Department of Oral and Maxillofacial Pathology, Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
Fatemeh Mohaghegh
Department of Dermatology and Dermatopathology, School of Medicine, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
Taha Mohagheghi
Department of Oral and Maxillofacial Pathology, Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran