Investigation of Lupus Nephritis Cases with Special Reference to Activity and Chronicity Indices
Publish place: Journal of Advanced Biomedical Sciences، Vol: 13، Issue: 2
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
View: 118
This Paper With 10 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_JABS-13-2_002
تاریخ نمایه سازی: 31 تیر 1402
Abstract:
Background & Objectives: The International Society of Nephrology/ Renal Pathology Society (ISN/RPS) classification is based upon criteria which differentiate acute and chronic phases of Lupus Nephritis. Activity/Chronicity Index grants us a higher insight on the level of pathological lesions and treatment outcome by examining the reversibility of lesions .The present investigation was done in order to highlight the importance of activity and chronicity indices in the course of Lupus Nephritis.
Materials & Methods: Seventy-three Kidney biopsy samples of Lupus Nephritis patients were examined. The information was recorded in a check-list and was then statistically analyzed.
Results: Lupus Nephritis is importantly age-related, frequency of Lupus Nephritis increases with age until the age of ۴۰ years; ۲۱–۴۰ years being the most frequent among studied patients. A prominent decline was seen after the age of ۴۰. Regardless of age, the occurrence was more frequent in females. Class IV was most frequent in all ages and in both sexes. Both Activity and Chronicity scores were slightly higher in females. Activity Index was higher in ages of ۱۱ to ۳۰ years, whereas Chronicity Index was highest in ۴۱ to ۵۰ years of age. The highest Activity Index was reported in Class IV while the highest Chronicity Index was reported in Class V. The least Activity Index was shown in Class VI while Classes II and I had the lowest Chronicity Index. Endocapillary hypercellularity was the most frequent active lesion and tubular atrophy was the most frequent chronic lesion. It is noteworthy that fibrotic crescents were significantly less common among chronic lesions.
Conclusion: Histopathological findings, clinical and para-clinical data could furnish more information on disease process, treatment, quality of life and mortality rate.
Keywords:
Authors
خشایار فرشید
School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
فرحناز نوروزنیا
Department of Pathology, Urmia University of Medical Sciences, Urmia, Iran
معصومه پورجبلی
Department of Pathology, Urmia University of Medical Sciences, Urmia, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :