Toxicity effects of lipid nanoparticles containing Artemisia absinthium L, essential oil on BRC-۰۳ breast cancer cell line

Abstract Background & Objective: According to research, breast cancer is the second most common cancer among women. Nanomaterials of various materials significantly increase the solubility, stability and effective drug delivery, and in recent years research on the effectiveness of essential oils and plant extracts on inhibiting the growth of cancer cells is expanding. Artemisia belongs to the Asteraceae family. In many studies, the effectiveness of the essential oil and extract of this plant on inhibiting the growth of cancer cells has been reported. Materials & Methods: In this experiment, nanoparticles containing Artemisia absinthium L essential oil (thistle) were first synthesized by homogenizer & sonication method and then their physicochemical properties were determined, such as particle size, particle size distribution, zeta potential, percentage of loading efficiency. Essential oils, particle shape. Then, the anti-apoptotic effect of lipid nanoparticles containing Artemisia essential oil in breast cancer cells (BRC-۰۳) was evaluated. Results: The results of cellular effect of lipid nanoparticles containing essential oil of Artemisia absinthium L (thistle) on breast cancer cells showed that increasing the concentration of lipid nanoparticles containing essential oil of this plant reduced the survival rate of cancer cells. Breast (BRC-۰۳) was purified compared to essential oil (p <۰.۰۵). Conclusion:  Nano-essential oil of this plant is effective in reducing the IC۵۰ of the drug and increasing the cytotoxicity of the essential oil of the plant. Lipid nanoparticles containing essential oil of Artemisia absinthium L (thistle) activated the apoptotic pathway in breast cancer cells.

Keywords:

Breast cancer , Artemisia absinthium L , Anti-apoptotic , nanoparticles