Helianthus Annuus Seed Hydro-Alcoholic Extract Chemical Composition and Effects on Body Weight and Blood Parameters among Iraqi Patients Suffering from Type ۲ Diabetes Mellitus

Background & Objectives: The purpose of the present study was to calibrate and analyze the effects of Helianthus annuus (H. annuus) seeds extract on body weight and blood parameters of type-۲ diabetic-mellitus (T۲DM) patients. Materials & Methods: Three-hundred cases of T۲DM patients were involved in this study including ۱۸۰ males and ۱۲۰ females and divided into two groups (each with ۱۵۰ members). The herbal extract of H. annuus with a concentration of ۵۰۰mg/kg was subjected to group۱ (case population), but group ۲ received normal diet for three months. Gas Chromatography mass spectrometry (GC/MS) was used to analyze H. annuus compounds. Results: Major H. annuus fraction included chlorogenic acid (CGA) being ۴۰%. The extract conferred significant decreasing effects on hypertension but not body weight and body mass index (BMI) values. The extract receiving group vs control group regarding the mean blood factors respectively included fast blood glucose (FBS) (۳۹.۲% vs ۳.۲۲%, p<۰.۰۰۰۱), cholesterol (۶.۹% vs ۳.۲۲%, p=۰.۰۲۳۷), triglyceride (۵.۴% vs ۲.۳۰, p=۰.۰۱۱۳), and increase in high-density lipoprotein (HDL) (۲۲.۳% vs ۵.۲۶%, p<۰.۰۰۱) and low-density lipoprotein (LDL) (۱% vs ۲.۶%, p=۰.۰۱۱۲).   Conclusion: H. annuus major compounds included CGA (۴۰%) contributed to the control of the hypertension, lipid profile and the blood factors among T۲DM patients compared to those patients who received normal diet. More detailed investigations by participation of higher number of patients are required in this regard.

Keywords:

Helianthus-annuus , Diabetes Mellitus type ۲ , blood factors