Effectiveness of oral administration of Fenugreek seed aqueous extract on excision wound healing in diabetic rats

Diabetes is one of the most common glandular diseases. Delay in wound healing process is known as a major challenge in these patients. Fenugreek is known to have therapeutic effects. Thus, the present study was conducted to investigate the oral administration of fenugreek seed aqueous extract (FSE) on wound healing in the experimental animal model. An excisional model was created on ۲۴ rats. Streptozotocin was administrated in order to induce the diabetes. A surgery was performed and a circular wound with a diameter of ۶ mm was created on the dorsal surface of each rat. Animals were divided into ۴ groups including non-diabetic, diabetic control and diabetic treated rats, with oral administration of different doses of FSE (۲۰۰ and ۴۰۰ mg/kg). The wound area, histological parameters, blood glucose and insulin levels were measured on days ۳, ۷ and ۱۶. The results showed that the wound area and blood glucose were significantly decreased in FSE-treated animals in comparison with diabetic control from day ۷ (P<۰.۰۵). It can be suggested to use oral fenugreek seed aqueous extract on improved the blood sugar and wound healing in diabetic rats.

Keywords:

Excision wound , Healing , fenugreek seed , Diabetic rat