An insight into Biopolymers and treatment strategies for wound healing

Wound healing is a multifactorial physiological process and a growing healthcare challenge affecting several million people worldwide. Chronic, non-healing wounds place a massive burden on healthcare systems and treatments remain difficult in clinical due to the complexity of the healing process. These chronic wounds especially diabetic wounds will ultimately lead to compromised mobility, so there is a demanding need for effective management and easy operative wound dressing. Biopolymers such as alginate, chitosan, collagen, hyaluronic acid, and silk fibroin are attracting constantly increasing interest as a class of materials with remarkable characteristics, such as biocompatibility, biodegradability, non-toxicity, as well as unique physicochemical properties. they provide a microenvironment favorable for the enhanced healing rate, and they have become promising candidates for various applications, including wound dressings, drug carriers, coating materials, tissue adhesion, etc. Recent research shows that further modification of biopolymers by novel techniques and tissue engineering offers development in their antibacterial activity, drug-releasing capability, immune-modulatory, and tissue regeneration. However, several challenges remain in developing an ideal biomaterial.The present article aims to review the type of biopolymers and potential biomaterials, highlighting advancements in naturally inspired wound dressings and drug delivery systems, also emerging approaches, and engineered devices for advanced wound care are reported.

Keywords:

biopolymers , wound healing , biomaterial , wound dressing