Effects of Iranian herbal Zofa® syrup for the management of clinical symptoms in patients with COVID-۱۹: A randomized clinical trial

Objective: The objective of this study was to determine the role of Iranian herbal Zofa® syrup in improving the clinical symptoms of patients with COVID-۱۹.Materials and Methods: This randomized clinical trial was conducted on ۱۰۵ patients with COVID-۱۹. Patients were randomly assigned to the intervention (n=۳۵) group (received ۱۰ ml of Zofa® syrup every ۸ hours/seven days plus standard treatment) or the control (n=۷۰) group (received only standard treatment). Assessments were performed before and after treatment.Results: The groups were comparable regarding age (p=۰.۹۸۰), gender (p=۰.۵۸۴), comorbidities (p=۰.۳۱۸), or drug history (p=۰.۷۷۱). There was no difference between patients' recovery status at the time of discharge (p=۰.۳۲۷) or two weeks post-discharge (p=۰.۱۶۵) in the intervention and control groups. No patient was hospitalized to the intensive care unit (ICU) for supplemental oxygen therapy and no patient died in the intervention group. However, in the control group, three (۴.۵%) patients were transferred to the ICU, and two (۳.۰۳%) patients died.Conclusion: Considering the better recovery status of the patients at the time of discharge and the absence of patient deaths in the intervention group, more additional studies are needed to confirm these findings and elucidate the role of Zofa® in COVID-۱۹.

Keywords:

Coronavirus disease ۲۰۱۹ , Herbal Medicine , Respiratory infection , Symptoms , Iran