Virgin Coconut Oil Supplementation as Ulcerative Colitis Prevention, Does it work? Clinical Correlation
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JMCH-6-12_031
تاریخ نمایه سازی: 18 شهریور 1402
Abstract:
Background and objectives: Ulcerative colitis (UC) is an inflammatory disease of the large intestine characterized by diffuse mucosal damage accompanied by ulceration. UC is associated with proinflammatory cytokines. Currently, many herbal medicines are used to prevent various diseases. One of them, virgin coconut oil (VCO), is thought to be used as UC therapy.Aims: To see the VCO supplementation effect as a prevention of Ulcerative Colitis by measuring inflammatory cytokine levels, Mouse Colitis Histopathology Index (MCHI) scores, and Disease Activity Index (DAI) scores.Materials and methods: This study used mice which were divided into ۵ groups, namely the KS group (mineral water), the KDSS group (dextran sodium sulfate (DSS) ۵%), the KL-VCO group (۵% DSS + VCO ۱۰۰۰ mg/kgBW/day), the KM-VCO group (DSS ۵% + VCO ۳۰۰۰ mg/kgBW/day), and the KH-VCO group (DSS ۵% + VCO ۹۰۰۰ mg/kgBW/day). The treatment lasted ۵ days, with observations of DAI score, MCHI score, and inflammatory cytokines (TNF-α, IL-۶, and IL-۱۰) were examined with an enzyme-linked immunosorbent assay (ELISA).Results: When compared to the KDDS control group, the IL-۱۰ levels of the treatment group that got VCO therapy went up as the doses of the KL-VCO group, the KM-VCO group, and the KH-VCO group went up in order. Besides, VCO therapy showed a decrease in IL-۶ levels, TNF-α levels, DAI scores, and MCHI scores with increasing sequential doses in the KL-VCO group, the KM-VCO group, and the KH-VCO group when compared to the KDDS control group.Conclusion: VCO supplementation can be used to prevent ulcerative colitis by increasing IL-۱۰ levels while reducing IL-۶, TNF-α, DAI, and MCHI scores. These effects can be caused by compounds in VCO with potential as anti-inflammatories and antioxidants.
Keywords:
anti , inflammatory Clinical correlation Ulcerative colitis Virgin coconut oil
Authors
Ni Made Rika Trismayanti
Doctoral Program in Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia, Department of Surgery, Division of Pediatric Surgery, Persahabatan General Hospital, Jakarta
Kusworini Handono
Department of Clinical Pathology, Faculty of Medicine, Brawijaya University, Malang, Indonesia
Dian Handayani
Department of Nutrition, Faculty of Health Science, Brawijaya University, Malang, Indonesia
Umi Kalsum
Department of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
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