A Green Approach for The Electrochemical Dimerization of Edaravone

Edaravone is a free radical scavenger and neuroprotective agent used for the treatmentof acute ischemic stroke and Amyotrophic Lateral Sclerosis (ALS) [۱]. Edaravone and itsderivatives are also renowned for their antitumor and hypoglycemic activities. Edaravone hasattracted the attention of many chemists due to its antioxidant property and free radical scavengingactivity [۲]. In this work, a green electrochemical method for the synthesis of new dimer ofedaravone is described. The electrochemical behavior of edaravone has been investigated indetailed at different pHs regions by cyclic voltammetry and coulometry. Cyclic voltammogramsof a edaravone shows an anodic peak, which correspond to the transformation of edaravone tocorresponding radical, through an irreversible one electron process. This could be considered as acriterion for the instability and reactivity of radical that is produced at the surface of electrode [۳].The electrochemical synthesis has been successfully performed in an undivided cell using graphiteelectrode without toxic reagents and solvents using an environmentally friendly method.