Synthesis of Novel ۱,۲,۳-Triazoles-linked Indoles Through Copper(I)-catalyzed Click Reactions
Publish place: Organic Chemistry Research، Vol: 7، Issue: 2
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_ORGC-7-2_011
تاریخ نمایه سازی: 3 مهر 1402
Abstract:
A series of novel ۱,۲,۳-triazoles-linked indole derivatives were prepared by the reaction of ۲-aryl-۱-(prop-۲-ynyl)-۱H-indole-۳-carbaldehydes with aryl azides via copper-catalyzed azide-alkyne cycloaddition reactions in the presence of sodium ascorbate, as a reducing agent. The effects of catalysts, solvents, and reaction temperature were investigated. Under the optimal condition, ۱,۲,۳-triazoles linked-indoles were obtained in ۶۳–۹۲% yields.
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Authors
Mohammad Bakherad
Faculty of Chemistry, Shahrood University of Technology, Shahrood ۳۶۱۹۹۹۵۱۶۱, Iran
Ali Keivanloo
Faculty of Chemistry, Shahrood University of Technology, Shahrood ۳۶۱۹۹۹۵۱۶۱, Iran
Narges Rahmani
Faculty of Chemistry, Shahrood University of Technology, Shahrood ۳۶۱۹۹۹۵۱۶۱, Iran
Leila Kamrani
Faculty of Chemistry, Shahrood University of Technology, Shahrood ۳۶۱۹۹۹۵۱۶۱, Iran