Rhinosporidiosis- Epidemiological, Clinicoradiological, Immunological Profile
Publish place: Iranian Journal of Otorhinolaryngology، Vol: 35، Issue: 5
Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
View: 102
This Paper With 8 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJOTO-35-5_003
تاریخ نمایه سازی: 4 مهر 1402
Abstract:
Introduction: Rhinosporidiosis is an enigmatic disease with many unsolved queries right from taxonomy to treatment. This study has been done to understand the disease characteristics with a peek into the lesser known immunological aspects of it by studying the changes in levels of certain primarily cell-mediated immunity (CMI)-specific cytokines in rhinosporidiosis patients.Materials and Methods:A prospective observational study was performed. Detailed epidemiological and clinicoradiological assessment was done along with selected inflammatory and immunological markers. The tests for immunological parameters were done by ELISA and CLIA and data were compiled and analyzed using appropriate statistics.Results:Disease showed male predominance and all patients gave a universal pond bathing history. Majority patients had O+ve blood group. Right side was affected most with nasal obstruction being commonest symptom. Nasal cavity was involved in majority of cases with inferior turbinate and meatus being sites of maximum occurrence and attachment. Nasopharynx, oropharynx were other involved sites. Extra-nasal sites included skin and parotid gland. Endoscopic and CECT findings were similar and confirmed intraoperatively. Tests for inflammatory markers showed no significant change in patients. Immunological markers -IL-۶, TNF-beta- levels showed significant increase though no such increase was found with IFN-gamma levels.Conclusion:Rhinosporidiosis has a definite epidemiological and clinical-radiological profile. A clear association with exposure to contaminated water is present which could not be further associated with disease duration or recurrence. The immunological profile needs to be further investigated upon since it remains quite elusive.
Authors
Megha Chandran
MS ENT, All India Institute of Medical Sciences Raipur
Rupa Mehta
ASSOCIATE PROFESOR , AIIMS RAIPUR
NITIN NAGARKAR
PROFESSOR AND HOD, DEPARTMENT OF ENT & HNS, AIIMS RAIPUR (CHHATTISGARH), INDIA
Anudita Bhargava
Professor and Head, Department of Microbiology, AIIMS, Raipur
Eli Mohapatra
Professor and Head, Department of Biochemistry, AIIMS Raipur
Saroj Pati
Associate Professor, Department of Radiology, AIIMS Raipur